Wednesday, February 29, 2012

The AEmperor of All Maladies

3 In the 1950s, people were terrified of cancer and did not want to talk about let alone face them. The New York Times refused to print the word “cancer” or “breast” for advertisement of cancer support-group. People have been terrified of cancer even though heart disease kills more people than cancer. In 1958, Science Digest reported that there were 450,000 new cases of cancer diagnosed each year and seven hundred thousand cases of cancer were being treated in America. In 1958, according to Patterns of Disease, one woman in four under the age of thirty-five could expect to get cancer, and one in seven would die from it; one man in five under the age of fifty would be afflicted, and one in eight would die. People tend to connect cancer to death immediately because cancers come out again and again after the doctors treated them. It is like the dead people come out again from the grave and eat people’s lives. I think that people’s feeling towards cancer and zombies are same. In 1950s, many doctors believed that cancer was not curable. Now people started to believe that cancer is curable. However, cancer’s nature of proliferation and invasion of nearby tissue in the body still scares people. Today, doctors and scientists believe that cancer is a genetic disease. For instance BRCA 1 and BRCA 2 genes cause breast cancer. In the future, people go to the oncologist’s clinic to check cancer genome for early prevention of these dreadful diseases.

4 Sidney Farber used anti-folate for leukemia treatment in 1947. Dr. Faber utilized folate analogues, which are chemical compounds that should reduce the growth of leukemia cells, and he tested his anti-folates on leukemia patients. It was a new treatment and first used by Sidney Farber to treat acute childhood leukemia. This finding encouraged other researchers to discover drugs that blocked different functions involved in cell growth and replication. This is the era of chemotherapy history. Siddhartha Mukherjee explains, “cancer as not one but many diseases.”

Sidney Farber devoted his life to save his cancer patients. He predicted that folic acid antagonists would inhibit or stop the proliferation of cancer cells. His research was used to find other chemotherapeutic agents. Under his influence and leadership, he founded the “Jimmy Fund”, which was one of the first comprehensive pediatric oncology treatment center, and the Children’s Cancer Research Foundation. Later this foundation became the Dana-Farber Cancer Institute.

5

Min Chiu Li was accused of using his patients for his experiments. He was not an American, but Chinese. So he was called an outsider. I feel that there are some cultural differences between Chinese and American. American people tend to put value about people’s feelings. Chiu Li had been studying cancer, therefore he knew the nature of recurrent cancer and he could recognize the sign of life for them. He cared about numbers and obsessed over the number “0” in order to reach an hcg level of 0. Therefore, he continued to treat chemotherapy drugs long after the patient looked well. It looked cold and heartless to care more about numbers for some doctors. I understand them because chemotherapy is horrible toxins to the body. Min Chiu Li lost his job for that, but he turned out to be right. Any trace of cancer was detected by indicators such as hcg level, where cancer relapsed some months later. What is worse, this relapse becomes more resistant to chemotherapy. When I had herpies because of stress, some American people believes that HIV causes these diseases. In Japan, it is very common in hihgly stressed people. I had to do many tests to prove that I did not have HIV. When I took medication, one doctor told me that if I took excess of drugs, I didn’t have any side-effects of disease like headache. I did not want to have a headache, so I took excess of medicines to fight back to this virus even through this doctor was reluctant to give me excess medications because of ethical issues. As a result, I am headache free my entire my life. So many people complain headache after this disease. Sometimes we need to take a risk to fight back against diseases. It is very difficult to deal with human bodies because we have exceptionally complicated bodies.

Monday, February 20, 2012

Cannibalistic cancer?

Cannibalistic cancer?

Cancer’s got a new enemy—drugs that block autophagy, the process of cellular cannibalism that is increased in many cancer cells. Presenting at AAAS, Ravi K. Amaravadi, an assistant professor of Medicine at the Perelman School of Medicine and Abramson Cancer Center at the University of Pennsylvania, argues that blocking the cell’s ability to degrade and recycle proteins can enhance a variety of cancer treatments.

Amaravadi and others have shown that hydroxychloroquine (HCQ), an approved malaria and rheumatoid arthritis treatment, can do just that. Laboratory models of treatment-resistant cancers and ongoing clinical trials have demonstrated that HCQ can enhance antitumor activity when combined with chemotherapy, targeted therapy, radiation, and immunotherapy.

“Our assays performed on human blood and tissue samples indicate that high doses of HCQ are required to block autophagy in patients, and in some cases, such as in a brain tumor trial, these high doses, in combination with specific anticancer agents, can lead to toxicity for the tumor,” Amaravadisaid in a press release. “While our knowledge of the role of autophagy in cancer is still in its infancy, the opportunity to learn about autophagy, both at the bench and the bedside, could accelerate the translation of basic advances in this field into clinical benefit for patients with cancer.”

Thursday, February 16, 2012

Farber's antifolates

Here is the paper published by the New England Journal of Medicine on Farber's antifolates. Quite interesting for a 64 year old paper.

http://www.nejm.org/doi/full/10.1056/NEJM194806032382301

Tuesday, February 14, 2012

The Emperor of All Maladies

1 Mukherjee started to face to cancer in 2003. He began advanced training in cancer medicine at the Cancer Institute in Boston in the summer of 2003. He was shocked to discover that chemotherapy and the tongue-twisting names of the drugs destroy patient’s precious lives or beautiful life-styles instead of curing them. Cancer is not modern diseases. Cancer has influenced humans throughout recorded history. Scientists found the evidence of cancer among fossilized bone tumors, the bone cancer, and bony skull in ancient Egypt. In that time, there was no treatment. However, Doctors started to understand cancer in the first 19th century. Cancer is a disease that starts when a single cell begin to grow out of control. Cancer begins with a small accident, or a mutation in one cell. However, we don’t understand how we could build, adapt and repair ourselves. If we could figure out all these mystery, we could find a way to repair cancer cells.

2 In his book, Mukherjee introduced two women: first, Carla Reed who is a young mother panicked for the sudden onset of leukaemia and second, Sidney Farber who first administered cytogenic drugs to leukaemia patients in the 1940s at Children’s Hospital Boston. The author describes cancer therapeutics, molecular biochemistry and genetics hoping to find out a cure to save Carla. Carla Reed is just 30 years old when she became ill. It could be bloodcurdling, desperate, and fear experience looking at lovely her three years old daughter.

Acute lymphocytic leukemia is a cancer of the lymphocytes. “Acute” means that the disease begins and gets worse quickly, so Carla needs immediate treatment. Carla found a few bruises on her back, and they vanished leaving large map-shaped marks on her back. It could be a dreadful event for any young women. Soon, she can’t walk up stairs. Then she can’t stand up. She crawled down the hallways of her house. When I had a back pain, I had to crawl down to the bathroom and it took one hour to get there. I could not tell you how I was miserable.

Carla and her husband saw a general physician, but nobody found her cancer. Cancer is a difficult to diagnosis, especially for young people. Can we blame doctors who can’t find cancer?

One of my friends missed urinary cancer of his patients 10 years ago. He still blames himself for his miss. To cure cancer is battle among scientists, doctors, pathologists, lab workers, other medical workers and patients. One word “curable” encourages doctors and patients. How a word is important for people’s lives. I can feel the author’s passion to find out best treatments for cancer to save young people’s lives and their families.



Next set of questions.. to be answered this week...

3. The author writes how in the early 1950's, the New York Times refused to print the word cancer or breast. Compare this to how we view cancer today.
4. SIdney Farber's early clinical experiments with antifolates in 1947 and 48 were a failure, with all his young leukemia patients eventually dying fo teh the disease. But with the results of these trials, Mukherjee writes, Farber saw a door open. Why do Farber's trials mark a turning point in the history of cancer research?
5. Review the case on Min Chiu Li (135-138) and explain why Freirich said that Li was accused of experimenting on people, but that he also states that everyone was experimenting .. to not experiment would mean to follow the old rules-to do absolutely nothing. Do you think Li's actions were ethical?

Monday, February 13, 2012

nanosensors and cancer biomarkers

A team led by Yale University researchers has used nanosensors to measure cancer biomarkers in whole blood for the first time. Their findings, which appeared December 13 in the advanced online publication of Nature Nanotechnology, could dramatically simplify the way physicians test for biomarkers of cancer and other diseases. The team, led by Yale's Dr. Mark Reed used nanowire sensors to detect and measure concentrations of two specific biomarkers: one for prostate cancer and the other for breast cancer

the wonders of p53

Researchers have identified a pathway that is elevated in p53-mutated cancers and that points to the potential for using cholesterol-lowering statins to help hold back cancer progression. Studies on 3-D breast cancer cell cultures by a Columbia University-led team found that p53 mutations elevate the cholesterol-synthesizing mevalonate pathway, which has been implicated in multiple aspects of tumorigenesis, including proliferation, survival, invasion, and metastasis. The cancer cells then appear to become dependent on this pathway for their continued survival, cancer phenotype, and invasive properties.

Breast cancer stem cells...

Scientists claim nanoparticle-mediated photothermal therapy could provide an effective therapeutic option for killing offcancer stem cells (CSCs) that are resistant to traditional forms of radiation and chemotherapy. Wake Forest School of Medicine researchers have found that while cancer stem cells from otherwise hard to treat triple negative breast cancer are largely resistant to traditional forms of hyperthermia, the local high levels of heat generated by carbon nanotubes subjected to laser light causes cell necrosis and rapid cell death of both CSCs and the bulk cancer cells.

Thursday, February 2, 2012

Questions from the book

Please answer these two questions ( do not read other responses, until you have posted yours)
All of you need to answer/respond to these 2 questions.
1. Cancer is described as a modern disease, yet its first description dates back to 2500 B.C. I what sens, then, is a cancer a disease of modern times? How does knowing its ancient history affect your notion of cancer?
2. The author frames the book around the story of his patient, Carla Reed. What was her diagnosis? what did you find interesting about Carla's experience? How do you think she shaped the author's life and thoughts?